Publications

2015

  • Retrotransposition and Crystal Structure of an Alu RNP in the Ribosome-Stalling Conformation

    Details PubMed

2014

  • Evolutionary relationship of two ancient protein superfolds

    Details PubMed

2013

  • Structure and properties of the esterase from non-LTR retrotransposons suggest a role for lipids in retrotransposition

    Details PubMed

  • NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain

    Details PubMed

2012

  • The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex

    Details PubMed

  • The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes

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  • Small RNA binding to the lateral surface of Hfq hexamers and structural rearrangements upon mRNA target recognition

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2011

  • Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition

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  • Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein

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2010

  • A method and server for predicting damaging missense mutations

    Details PubMed

2009

  • Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival

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2008

  • Active Alu retrotransposons in the human genome

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  • Hypermutable non-synonymous sites are under stronger negative selection

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  • Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes

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  • Assessing the evolutionary impact of amino acid mutations in the human genome

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  • Proportionally more deleterious genetic variation in European than in African populations

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2007

  • A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting

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  • Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol

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  • Medical sequencing at the extremes of human body mass

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2005

  • Small fitness effect of mutations in highly conserved non-coding regions

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  • A limited role for balancing selection

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  • Integration of genomic data in Electronic Health Records--opportunities and dilemmas

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  • Metabolites and pathway flexibility

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2004

2003

  • Systematic discovery of analogous enzymes in thiamin biosynthesis

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  • Metabolites: a helping hand for pathway evolution?

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  • STRING: a database of predicted functional associations between proteins

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2002

  • Two (βα)8-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates

    Details PubMed

  • A common evolutionary origin of two elementary enzyme folds

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  • A versatile structural domain analysis server using profile weight matrices

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2001

  • Medical target prediction from genome sequence: combining different sequence analysis algorithms with expert knowledge and input from artificial intelligence approaches

    Details PubMed